I was going through some Amazing Stories and found out that they reprinted H.G.Wells's classic The Island of Dr. Moreau. I had never read it before, so I thought I'd give it a try!
The book was originally published in 1896, and there's a famous 1996 film that I never saw, but I did hear a bit about. Still, I knew little enough that the story was a bit of a surprise.
It combines a shipwreck story--a popular form back in the day--with dark, biological science fiction. It's written from the point of view of Edward Prendick, an English natural historian.